EFSA：一种6'-唾液乳糖钠盐作为新型食品的安全性
文章来源： 作者： 发布日期：2022-12-19 浏览次数： 1108 次
2022年12月7日，据欧盟食品安全局（EFSA）消息，欧盟营养、新型食品和食物过敏源（NDA）研究小组就一种6'-唾液乳糖钠盐（6′-sialyllactose (6’-SL) sodium salt）作为新型食品的安全性发表科学意见。
据了解，该6'-唾液乳糖钠盐是由大肠杆菌BL21 (DE3)的衍生菌株生产的。经过评估，专家小组得出结论，在提议的使用条件下，6'-唾液乳糖钠盐作为新型食品是安全的。部分原文报道如下：
Following a request from the European Commission, the EFSA Panel
on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver
an opinion on 6′-sialyllactose (6’-SL) sodium salt as a novel food (NF)
pursuant to Regulation (EU) 2015/2283. The NF is mainly composed of the
human-identical milk oligosaccharide (HiMO) 6’-SL, but it also contains
d-lactose, 6′-sialyllactulose, sialic acid, N-acetyl-d-glucosamine and a
small fraction of other related oligosaccharides. The NF is produced by
fermentation with two genetically modified strains of Escherichia coli
BL21 (DE3), the production strain and the optional degradation
strain. The information provided on the identity, manufacturing process,
composition and specifications of the NF does not raise safety
concerns. The applicant intends to add the NF to a variety of foods,
including infant formula and follow-on formula, food for special medical
purposes and food supplements. The target population is the general
population. In some scenarios at the maximum use levels, the estimated
intakes per kg body weight were higher than the high average natural
intake of 6’-SL from human milk. However, given the intrinsic nature of
human milk oligosaccharides (HMOs), the wide range of intakes from human
milk, and considering that infants are naturally exposed to similar amounts of these substances, the Panel considers that the consumption of the NF at the proposed conditions
of use does not raise safety concerns. The intake of 6’-SL in breastfed
infants on a body weight basis is also expected to be safe for other
population groups. The intake of other carbohydrate-type compounds
structurally related to 6’-SL is also considered of no safety concern. Food supplements are not intended to be used if other foods with added 6’-SL or human milk are consumed on the same day. The Panel concludes that the NF is safe under the proposed conditions of use.
